Pathogenesis of intraventricular haemorrhage in newborn infants
Open Access
- 1 September 1974
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 49 (9), 722-728
- https://doi.org/10.1136/adc.49.9.722
Abstract
The ventricular CSF of a group of preterm infants dying in the newborn period contained a large excess of protein which appeared to be a plasma filtrate. This excess was found whether or not an intraventricular haemorrhage (IVH) was also present. After consideration of the clinical features of the infants, their coagulation status, and the findings at necropsy, we suggest that increased cerebral venous and capillary pressure, usually caused by heart failure resulting from hypoxia and acidosis, was responsible both for the IVH, by rupturing the terminal veins, and for promoting the filtration of plasma proteins into the CSF. Abnormalities of haemostasis, though very common, did not seem to provide an adequate explanation for the initiation of intraventricular bleeding, though they may have exacerbated it.Keywords
This publication has 25 references indexed in Scilit:
- CONTINUOUS POSITIVE AIRWAY PRESSURE AND HYDROCEPHALUSThe Lancet, 1973
- INTRACRANIAL HAEMORRHAGE IN LOW-BIRTH-WEIGHT INFANTS AND PROPHYLACTIC ADMINISTRATION OF COAGULATION-FACTOR CONCENTRATEThe Lancet, 1973
- Controlled trial of fresh frozen plasma in asphyxiated low birthweight infantsArchives of Disease in Childhood, 1973
- Perinatal cerebral intraventricular hemorrhageThe Journal of Pediatrics, 1972
- Certain Causes of Neonatal Death. IV. Massive Pulmonary HaemorrhageNeonatology, 1971
- INTRAVASCULAR COAGULATION AND HYALINE-MEMBRANE DISEASEThe Lancet, 1968
- Improved automated methods of protein determination.Journal of Clinical Pathology, 1968
- INTRACRANIAL HÆMORRHAGE AND CLOTTING DEFECTS IN LOW-BIRTH-WEIGHT INFANTSThe Lancet, 1968
- Intracranial haemorrhage associated with hyaline membrane disease.Archives of Disease in Childhood, 1968
- Some properties of the α2 and γ2 subunits of foetal haemoglobinJournal of Molecular Biology, 1962