Synthesis and fungicidal activity of novel 1,2,4-triazole derivatives containing a pyrimidine moiety
- 27 June 2019
- journal article
- research article
- Published by Taylor & Francis Ltd in Phosphorus, Sulfur, and Silicon and the Related Elements
- Vol. 194 (12), 1171-1175
- https://doi.org/10.1080/10426507.2019.1633321
Abstract
A series of novel 1,2,4-triazole derivatives containing a pyrimidine moiety were synthesized and their fungicidal activities were evaluated. The preliminary biological test indicated that some of the target compounds exhibited moderate to good fungicidal activities against the tested plant pathogenic fungi compared with the commercial agent. Among them, compounds 9n and 9o exhibited excellent antifungal activity against Phompsis sp., with the half-maximal effective concentration (EC50) values of 25.4 and 31.6 μg/mL, which were even better than the commercial agent of Pyrimethanil (32.1 μg/mL). Meanwhile, compound 9o showed better fungicidal activities against B. dothidea and B. cinerea with 40.1 and 55.1 μg/mL, respectively, in comparison with that of commercial Pyrimethanil (57.6 and 62.8 μg/mL).Keywords
Funding Information
- Natural Science Foundation of the Department of Education of Guizhou Province ([2016]091)
- Guizhou Science and Technology Fund Project ([2016]1006)
- National Natural Science Foundation of China (31701821, 21462010)
- Guiyang Science and Technology Bureau and Guiyang University (GYU-KYZ[2018]01-09, 2017M623070)
This publication has 27 references indexed in Scilit:
- Synthesis and antiviral activity of 2-substituted methylthio-5-(4-amino-2-methylpyrimidin-5-yl)-1,3,4-oxadiazole derivativesBioorganic & Medicinal Chemistry Letters, 2015
- Synthesis and quantitative structure–activity relationship (QSAR) analysis of some novel oxadiazolo[3,4-d]pyrimidine nucleosides derivatives as antiviral agentsBioorganic & Medicinal Chemistry Letters, 2015
- The Synthesis and Herbicidal Activity of 5‐(Substituted‐phenyl)‐4,6‐dioxo −4,5,6,7‐tetrahydropyrazolo[3,4‐d]pyrimidinesJournal of Heterocyclic Chemistry, 2014
- Development of Two Scalable Syntheses of 4-Amino-5-aminomethyl-2-methylpyrimidine: Key Intermediate for Vitamin B1Organic Process Research & Development, 2011
- Synthesis and Antifungal Activity of Novel Sulfone Derivatives Containing 1,3,4-Oxadiazole MoietiesMolecules, 2011
- Synthesis and bioactivity of novel sulfone derivatives containing 2,4-dichlorophenyl substituted 1,3,4-oxadiazole/thiadiazole moiety as chitinase inhibitorsPesticide Biochemistry and Physiology, 2011
- Synthesis, antifungal activity and CoMFA analysis of novel 1,2,4-triazolo[1,5-a]pyrimidine derivativesEuropean Journal of Medicinal Chemistry, 2008
- Synthesis, pulse radiolysis, and in vitro radioprotection studies of melatoninolipoamide, a novel conjugate of melatonin and α-lipoic acidBioorganic & Medicinal Chemistry, 2006
- Antifungal Activity of 4-Methyl-6-alkyl-2H-pyran-2-onesJournal of Agricultural and Food Chemistry, 2006
- Studies on Pyrimidines Related to Vitamin B1. I. A New Synthesis of 2-Methyl-6-aminopyrimidine-5-aldehydeJournal of the American Chemical Society, 1940