Diagnosis of Human Lymphoma with Monoclonal Antileukocyte Antibodies
- 24 November 1983
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 309 (21), 1275-1281
- https://doi.org/10.1056/nejm198311243092102
Abstract
Two monoclonal antibodies have been produced that react with antigens present on human white cells. These reagents differ from other monoclonal antibodies of similar specificity in that the antigens they recognize are resistant to conventional tissue-fixation and embedding procedures. These reagents can therefore be used in immunocytochemical staining of paraffin-embedded tissue sections. We assessed the practical usefulness of this technique in the histopathological diagnosis of human lymphoid neoplasms by staining a wide range of routine surgical biopsy specimens of normal and neoplastic tissue (gathered from five institutions), using an indirect immunoperoxidase technique.This publication has 19 references indexed in Scilit:
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