Apoptosis in AIDS
- 28 May 1993
- journal article
- perspectives
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 260 (5112), 1269-1270
- https://doi.org/10.1126/science.8098552
Abstract
Infection with the human immunodeficiency virus type 1 (HIV-1) leads to progressive immunodeficiency and onset of opportunistic infections and neoplasms. The loss of immune competence is associated with declines in both the functionality and the number of CD4+ lymphocytes. Multiple mechanisms have been proposed to explain death and dysfunction of CD4+ T-cells. The mechanisms of HIV-1-mediated cell death which are relevant are unclear at present. However, explorations on the cytopathic effects of HIV-1 have yielded a wealth of potential triggering events, and signaling and effector pathways leading to apoptosis. The types of pro- and anti-apoptotic stimuli that have been associated with HIV-1 are multiple and often appear overlapping or even contradictory. This review focuses on the various molecular determinants from HIV-1 that play a role in induction of apoptosis in T-lymphocytes.Special attention is devoted to the viral genes, and , for which a significant body of literature on apotosis-related effects is available.Keywords
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