Association of Dietary Intake of Soy, Beans, and Isoflavones With Risk of Cerebral and Myocardial Infarctions in Japanese Populations
- 27 November 2007
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 116 (22), 2553-2562
- https://doi.org/10.1161/circulationaha.106.683755
Abstract
Background— Soy and isoflavones have been proposed to reduce the risk of cardiovascular risk factors, but their potential as preventatives for cardiovascular disease remains uncertain. We investigated the association of soy and isoflavone intake with risk of cerebral and myocardial infarctions (CI and MI). Methods and Results— To examine the association of soy and isoflavone intake with the risk of CI and MI, we studied 40 462 Japanese (40 to 59 years old, without cardiovascular disease or cancer at baseline). They completed a food-frequency questionnaire (1990–1992) and received follow-up to 2002. After 503 998 person-years of follow-up, we documented incidence of CI (n=587) and MI (n=308) and of mortality for CI and MI combined (n=232). For women, the multivariable hazard ratios and 95% confidence limits for soy intake ≥5 times per week versus 0 to 2 times per week were 0.64 (0.43 to 0.95) for risk of CI, 0.55 (0.26 to 1.09) for risk of MI, and 0.31 (0.13 to 0.74) for cardiovascular disease mortality. Similar but weaker inverse associations were observed between intake of miso soup and beans and risk of cardiovascular disease mortality. The multivariable hazard ratios for the highest versus the lowest quintiles of isoflavones in women were 0.35 (0.21 to 0.59) for CI, 0.37 (0.14 to 0.98) for MI, and 0.87 (0.29 to 2.52) for cardiovascular disease mortality. An inverse association between isoflavone intake and risk of CI and MI was observed primarily among postmenopausal women. No significant association of dietary intake of soy, miso soup, and beans and isoflavones with CI or MI was present in men. Conclusions— High isoflavone intake was associated with reduced risk of CI and MI in Japanese women. The risk reduction was pronounced for postmenopausal women.This publication has 40 references indexed in Scilit:
- Soy Protein, Isoflavones, and Cardiovascular HealthCirculation, 2006
- Prospective Study on Usual Dietary Phytoestrogen Intake and Cardiovascular Disease Risk in Western WomenCirculation, 2005
- Alcohol Consumption and Risk of Stroke Among Middle-Aged Men: The JPHC Study Cohort IStroke, 2004
- Cholesterol, coronary heart disease, and stroke in the Asia Pacific regionInternational Journal of Epidemiology, 2003
- Relation between soy-associated isoflavones and LDL and HDL cholesterol concentrations in humans: a meta-analysisEuropean Journal of Clinical Nutrition, 2003
- The Role of Vitamin E in the Prevention of Heart DiseaseArchives of Family Medicine, 1999
- Antioxidant Activity of Phytoestrogenic IsoflavonesFree Radical Research, 1997
- Biological effects of isoflavones in young women: importance of the chemical composition of soyabean productsBritish Journal of Nutrition, 1995
- A Diet Moderately Enriched in Phytosterols Lowers Plasma Cholesterol Concentrations in Normocholesterolemic HumansAnnals of Nutrition and Metabolism, 1995
- Influence of total cholesterol, high density lipoprotein cholesterol, and triglycerides on risk of cerebrovascular disease: the Copenhagen city heart studyBMJ, 1994