Secondary mycosis in surgery: Treatment with fluconazole
- 1 March 1989
- journal article
- review article
- Published by Springer Science and Business Media LLC in Infection
- Vol. 17 (2), 111-117
- https://doi.org/10.1007/bf01646895
Abstract
Summary Together with the severity of the underlying disease, mycotic infections are assuming increasing significance in surgical patients under intensive care. 26 patients with severe internal mycotic infections were treated with fluconazole in an open clinical trial. The pathogens isolated wereCandida albicans in 22 cases,Candida tropicalis in four,Torulopsis glabrata in three,Candida parapsilosis in two andAspergillus fumigatus in one. Mixed infections were found in five cases. Most of this series of surgical patients had a severe, life-threatening post-operative condition. Their mean classification by the Apache score was 15.35. The most frequent risk factors were previous injuries to intraabdominal hollow organs and extensive antibiotic therapy; and the peritoneum was, therefore, the commonest site of infection. Antimycotic therapy was with fluconazole at a dose of 200–400 mg daily for at least ten days. The mycosis was cured in 22 of the 26 patients, one of these being a case of severe mycotic peritonitis. Nine patients died of the underlying disease within four weeks of the beginning of treatment. Fluconazole was effective and well tolerated in the treatment of severe life-threatening infections in surgical patients.Keywords
This publication has 15 references indexed in Scilit:
- Etiologic Organisms as Independent Predictors of Death and Morbidity Associated with Bloodstream InfectionsThe Journal of Infectious Diseases, 1987
- Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbitsAntimicrobial Agents and Chemotherapy, 1986
- Pharmacokinetic evaluation of UK-49,858, a metabolically stable triazole antifungal drug, in animals and humansAntimicrobial Agents and Chemotherapy, 1985
- Candida Infections in Surgical Patients Dose Requirements and Toxicity of Amphotericin BAnnals of Surgery, 1982
- APACHE—acute physiology and chronic health evaluation: a physiologically based classification systemCritical Care Medicine, 1981
- Kreuzreaktionen von 8 Sprosspilzarten und ihre Bedeutung für die serologische Candida DiagnostikMedical Microbiology and Immunology, 1979
- Infections caused by arterial catheters used for hemodynamic monitoringAmerican Journal Of Medicine, 1979
- Hospital-acquired fungemia: Its natural course and clinical significanceAmerican Journal Of Medicine, 1979
- Venous catheter-associated candidemiaThe American Journal of the Medical Sciences, 1978
- The risk of positive cultures for Candida in the critically ill patientCritical Care Medicine, 1978