Animal Models of Cardiac Disease and Stem Cell Therapy
Open Access
- 26 November 2010
- journal article
- Published by Bentham Science Publishers Ltd. in The Open Cardiovascular Medicine Journal
- Vol. 4 (1), 231-239
- https://doi.org/10.2174/1874192401004010231
Abstract
Animal models that mimic cardiovascular diseases are indispensable tools for understanding the mechanisms underlying the diseases at the cellular and molecular level. This review focuses on various methods in preclinical research to create small animal models of cardiac diseases, such as myocardial infarction, dilated cardiomyopathy, heart failure, myocarditis and cardiac hypertrophy, and the related stem cell treatment for these diseases.Keywords
This publication has 99 references indexed in Scilit:
- Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarctionNature Medicine, 2006
- Dystrophin disruption in enterovirus-induced myocarditis and dilated cardiomyopathy: from bench to bedsideMedical Microbiology and Immunology, 2004
- The Obesity-Associated Peptide Leptin Induces Hypertrophy in Neonatal Rat Ventricular MyocytesCirculation Research, 2003
- Adenovirus-Mediated Overexpression of Caveolin-3 Inhibits Rat Cardiomyocyte HypertrophyHypertension, 2003
- Statins as antioxidant therapy for preventing cardiac myocyte hypertrophyJCI Insight, 2001
- Peptides Derived from Cardiovascular G-protein-coupled Receptors Induce Morphological Cardiomyopathic Changes in Immunized RabbitsJournal of Molecular and Cellular Cardiology, 1997
- Autoimmunity in Myocarditis: Models and MechanismsClinical Immunology and Immunopathology, 1993
- Prevalence and etiology of idiopathic dilated cardiomyopathy (summary of a National Heart, Lung, and Blood Institute Workshop)The American Journal of Cardiology, 1992
- A novel experimental model of giant cell myocarditis induced in rats by immunization with cardiac myosin fractionClinical Immunology and Immunopathology, 1990
- Cardiac Hypertrophy in HypertensionThe New England Journal of Medicine, 1987