Tick-borne encephalitis is associated with low levels of interleukin-10 in cerebrospinal fluid
Open Access
- 1 January 2011
- journal article
- Published by Informa UK Limited in Infection Ecology & Epidemiology
- Vol. 1 (1)
- https://doi.org/10.3402/iee.v1i0.6029
Abstract
Tick-borne encephalitis (TBE) is associated with higher morbidity and induces a stronger intrathecal immune activation than most other viral induced meningo-encephalitis. The aim of this study was to investigate cytokine concentrations in cerebrospinal fluid (CSF) and serum in relation to aetiology and clinical course. Cytokines were analysed by Enzyme-linked Immuno Assay (ELISA) from 44 patients with TBE and from 36 patients with aseptic meningo-encephalitis of other aetiology (non-TBE). Significantly increased CSF levels of Interferon-γ (IFN-γ), Interleukin-10 (IL-10), Interleukin-6 (IL-6), Interleukin-1 receptor antagonist (IL- 1ra), and soluble CD8 receptor (sCD8) were detected in both cohorts. Tumour necrosis factor-α (TNF-α showed low levels or was not detected in CSF in any group in the acute stage. However, the CSF levels of IL- 10 were significantly lower in TBE than in non-TBE cases 06 days after onset of encephalitis. The TBE patients with encephalitis had significantly lower IL-10 CSF levels later in the clinical course (day 718) than TBE patients with meningeal disease. Increased IFN-γ production, but low IL-10 secretion, may be of pathophysiological significance in TBE. Keywords: tick-borne encephalitis; viral; cytokines; cerebrospinal fluid; pathophysiology (Published: 11 February 2011) Citation: Infection Ecology and Epidemiology 2011, 1: 6029 - DOI: 10.3402/iee.v1i0.6029Keywords
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