Enantioselective Electroreductive Coupling of Alkenyl and Benzyl Halides via Nickel Catalysis
Top Cited Papers
- 25 July 2019
- journal article
- research article
- Published by American Chemical Society (ACS) in ACS Catalysis
- Vol. 9 (8), 6751-6754
- https://doi.org/10.1021/acscatal.9b01785
Abstract
An electrochemically-driven enantioselective nickel-catalyzed reductive cross-coupling of alkenyl bromides and benzyl chlorides is reported. The reaction forms products bearing allylic stereogenic centers with good enantioselectivity under mild conditions in an undivided cell. Electrochemical activation and turnover of the cata-lyst mitigate issues posed by metal powder reductants. This report constitutes the first example of an enantiose-lective electroreductive cross-coupling.Keywords
Funding Information
- Division of Graduate Education (DGE-1144469)
- National Institute of General Medical Sciences (R35GM118191-01)
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