Aging, Atherosclerosis, and IGF-1
Open Access
- 5 April 2012
- journal article
- review article
- Published by Oxford University Press (OUP) in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences
- Vol. 67 (6), 626-639
- https://doi.org/10.1093/gerona/gls102
Abstract
Insulin-like growth factor 1 (IGF-1) is an endocrine and autocrine/paracrine growth factor that circulates at high levels in the plasma and is expressed in most cell types. IGF-1 has major effects on development, cell growth and differentiation, and tissue repair. Recent evidence indicates that IGF-1 reduces atherosclerosis burden and improves features of atherosclerotic plaque stability in animal models. Potential mechanisms for this atheroprotective effect include IGF-1–induced reduction in oxidative stress, cell apoptosis, proinflammatory signaling, and endothelial dysfunction. Aging is associated with increased vascular oxidative stress and vascular disease, suggesting that IGF-1 may exert salutary effects on vascular aging processes. In this review, we will provide a comprehensive update on IGF-1's ability to modulate vascular oxidative stress and to limit atherogenesis and the vascular complications of aging.Keywords
This publication has 153 references indexed in Scilit:
- Differential requirement for nitric oxide in IGF-1-induced anti-apoptotic, anti-oxidant and anti-atherosclerotic effectsFEBS Letters, 2011
- Impairment of IGF-I expression and anabolic signaling following ischemia/reperfusion in skeletal muscle of old miceExperimental Gerontology, 2011
- Thiazolidinediones Up-regulate Insulin-like Growth Factor-1 Receptor via a Peroxisome Proliferator-activated Receptor γ-Independent PathwayOnline Journal of Public Health Informatics, 2010
- Reactive Oxygen Species Enhance Insulin SensitivityCell Metabolism, 2009
- 12/15‐Lipoxygenase Products Induce Inflammation and Impair Insulin Signaling in 3T3‐L1 AdipocytesObesity, 2009
- Functionally significant insulin-like growth factor I receptor mutations in centenariansProceedings of the National Academy of Sciences of the United States of America, 2008
- Relationship Between Low Levels of Anabolic Hormones and 6-Year Mortality in Older MenThe Aging in the Chianti Area (InCHIANTI) StudyArchives of Internal Medicine, 2007
- The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis miceProceedings of the National Academy of Sciences of the United States of America, 2006
- The Molecular Inflammatory Process in AgingAntioxidants and Redox Signaling, 2006
- Insulin signalling and the regulation of glucose and lipid metabolismNature, 2001