Relative prognostic value of TNM7 vs TNM6 in staging oesophageal cancer
Open Access
- 16 August 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in British Journal of Cancer
- Vol. 105 (6), 842-846
- https://doi.org/10.1038/bjc.2011.320
Abstract
Stage migration consequent upon new cancer staging definitions may result in artifactual alterations in stage-specific survival and prognosis. The aim of this study was to determine the influence of the new TNM7 oesophageal cancer (OC) system on stage categorisation and survival when compared with historical controls. A total of 202 patients diagnosed with operable OC and undergoing oesophagectomy (118 neoadjuvant chemotherapy) were studied. Patients originally classified and staged using TNM6 were retrospectively re-staged using TNM7. Re-classification of TNM7 resulted in stage migration in 11.9% of patients (9.9% downstaged, 2.0% upstaged) when compared with TNM6. Five-year survival for stages I, II and III was 78%, 46% and 18% using TNM6, compared with 62%, 51% and 18%, respectively, using TNM7. Univariable analysis revealed that histological grade (P=0.006), pT (PPPPPPP<0.0001) were all associated with survival. Multivariable analysis revealed that only the TNM7 prognostic group was independently and significantly associated with survival. TNM7 is a better prognostic tool than TNM6 and represents an important advance in staging OC.Keywords
This publication has 54 references indexed in Scilit:
- Complete exon sequencing of all known Usher syndrome genes greatly improves molecular diagnosisOrphanet Journal of Rare Diseases, 2011
- An Update on the Genetics of Usher SyndromeJournal of Ophthalmology, 2010
- Frequency of Usher syndrome in two pediatric populations: Implications for genetic screening of deaf and hard of hearing childrenGenetics in Medicine, 2010
- PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndromeJCI Insight, 2010
- Mutation profile of theCDH23 gene in 56 probands with Usher syndrome type IHuman Mutation, 2008
- Survey of the frequency of USH1 gene mutations in a cohort of Usher patients shows the importance of cadherin 23 and protocadherin 15 genes and establishes a detection rate of above 90%Journal of Medical Genetics, 2006
- Recommended procedure for tympanometry: British Society of AudiologyBritish Journal of Audiology, 1992
- The Will Rogers PhenomenonThe New England Journal of Medicine, 1985
- Partial residuals for the proportional hazards regression modelBiometrika, 1982
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958