Haplotypes comprising subtypes of the DQB1*06 allele direct the antibody response after immunisation with hepatitis B surface antigen
- 1 October 1998
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 52 (4), 374-380
- https://doi.org/10.1111/j.1399-0039.1998.tb03058.x
Abstract
Two HLA class II haplotypes, HLA-[DQB1*0602; DQA1*0102; DR15] and HLA-[DQB1*0603; DQA1*0103; DRB1*1301] were found to be less common in 52 nonresponders compared with 68 responders, P100 IU/l respectively. The three haplotypes comprise either of three different DQB1*06 subtypes. Two of the seven amino acids that differ between the two responder alleles DQB1*0602 and *0603 and the nonresponder allele *0604 are located in the peptide-binding groove of the DQB1 molecule. In addition to this finding, amino acid 86 in the DRB1 molecule seems to determine the response against HBsAg. DRB1*1301 and DR15 in the responder haplotypes have a Val at this position while the nonresponder haplotype has a Gly. These results suggest a role for both the DQB1*06 alleles and the DRB1 alleles *1301, *1302 and DR15 to direct either a response or a nonresponse against HBsAg. Sixteen HLA class II genotypes were found to be shared by 25 nonresponders and 32 responders. This finding of HLA-identical nonresponders and responders indicates an influence of other genetic factors in addition to the HLA system in the response to HBsAg.Keywords
This publication has 26 references indexed in Scilit:
- Contribution of HLA class I and class II alleles to the regulation of antibody production to hepatitis B surface antigen in humansInternational Immunology, 1996
- Influence of smoking on immunological responses to hepatitis B vaccineVaccine, 1994
- HLA DOA‐DQB HAPLOTYPES IN A SWEDISH POPULATIONInternational Journal of Immunogenetics, 1993
- Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1Nature, 1993
- Genetic basis of nonresponse to hepatitis B vaccine in hemodialyzed patientsJournal of Hepatology, 1990
- HLA‐associated non‐responsiveness to Hepatitis B vaccineTissue Antigens, 1990
- Genetic Prediction of Nonresponse to Hepatitis B VaccineNew England Journal of Medicine, 1989
- Rapid DNA purification for restriction fragment length polymorphism analysisGene Analysis Techniques, 1988
- Immune suppression gene on HLA-Bw54-DR4-DRw53 haplotype controls nonresponsiveness in humans to hepatitis B surface antigen via CD8+ suppressor T cellsHuman Immunology, 1988