T cell receptor signalling networks: branched, diversified and bounded
- 25 March 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Immunology
- Vol. 13 (4), 257-269
- https://doi.org/10.1038/nri3403
Abstract
Engagement of antigen-specific T cell receptors (TCRs) is a prerequisite for T cell activation. Acquisition of appropriate effector T cell function requires the participation of multiple signals from the T cell microenvironment. Trying to understand how these signals integrate to achieve specific functional outcomes while maintaining tolerance to self is a major challenge in lymphocyte biology. Several recent publications have provided important insights into how dysregulation of T cell signalling and the development of autoreactivity can result if the branching and integration of signalling pathways are perturbed. We discuss how these findings highlight the importance of spatial segregation of individual signalling components as a way of regulating T cell responsiveness and immune tolerance.Keywords
This publication has 105 references indexed in Scilit:
- Biophysical mechanism of T-cell receptor triggering in a reconstituted systemNature, 2012
- Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen ReceptorImmunity, 2011
- Regulating Rap small G-proteins in time and spaceTrends in Cell Biology, 2011
- Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal TransductionImmunity, 2010
- Cooperative interactions at the SLP-76 complex are critical for actin polymerizationThe EMBO Journal, 2010
- CD45-Csk Phosphatase-Kinase Titration Uncouples Basal and Inducible T Cell Receptor Signaling during Thymic DevelopmentImmunity, 2010
- Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based MotifCell, 2008
- Cellular Image Analysis and Imaging by Flow CytometryClinics In Laboratory Medicine, 2007
- The Stimulatory Potency of T Cell Antigens Is Influenced by the Formation of the Immunological SynapseImmunity, 2007
- Thymic selection threshold defined by compartmentalization of Ras/MAPK signallingNature, 2006