Aerobic training in older adults with type 2 diabetes and vasodepressive carotid sinus hypersensitivity
- 22 October 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in Aging Clinical and Experimental Research
- Vol. 25 (6), 651-657
- https://doi.org/10.1007/s40520-013-0160-4
Abstract
Vasodepressive carotid sinus hypersensitivity (V-CSH) is a common but incurable etiology for fainting in older adults with diabetes (OADM), and is diagnosed by carotid sinus massage (CSM). Aerobic exercise has been shown to be an effective therapy for other neuroautonomic etiologies of syncope (such as orthostatic hypotension), but the effectiveness of aerobic training in V-CSH remains unknown. We examined whether aerobic training could attenuate the vasodepressive response to CSM in OADM (older adults with type 2 diabetes) subjects complicated by V-CSH. Forty OADM subjects (mean age 72.2 ± 0.7) complicated by V-CSH were recruited. Subjects were randomized to each of two groups: an aerobic group (AT, n = 20, 3 months vigorous aerobic exercise), and a nonaerobic (NA, n = 20, no aerobic exercise) group. Exercise sessions were supervised by a certified exercise trainer three times per week. The vasodepressive response [defined as the decrease in systolic blood pressure (SBP) during CSM] was measured before and after the training intervention using a Finometer. The intervention had no impact on the number of subjects that met the criteria for V-CSM in either the AT or NA groups, regardless of the criteria used (−10, −20, −30, −40 and −50 mmHg). There was no training effect on the vasodepressive response in either the AT or NA group (P = 0.214, 2-way analysis of variance, −30 mmHg definition for V-CSH). Aerobic training has no effect on the SBP response to CSM in OADM subjects with V-CSH. Unlike in other neuroautonomic etiologies for fainting, aerobic exercise is not effective as a treatment for V-CSH, at least in the OADM population.Keywords
This publication has 25 references indexed in Scilit:
- Arterial stiffness and the response to carotid sinus massage in older adultsAging Clinical and Experimental Research, 2010
- Short-Term Aerobic Exercise Reduces Arterial Stiffness in Older Adults With Type 2 Diabetes, Hypertension, and HypercholesterolemiaDiabetes Care, 2009
- The management of patients with carotid sinus syndrome: is pacing the answer?Clinical Autonomic Research, 2004
- Older Women With Diabetes Have a Higher Risk of FallsDiabetes Care, 2002
- Carotid sinus syndrome: a modifiable risk factor for nonaccidental falls in older adults (SAFE PACE)Journal of the American College of Cardiology, 2001
- Carotid sinus hypersensitivity--a modifiable risk factor for fractured neck of femur.Age and Ageing, 2000
- New Insights Into the Pathophysiology of Carotid Sinus SyndromeCirculation, 1996
- Pathophysiology of carotid sinus hypersensitivity in elderly patientsThe Lancet, 1995
- Carotid sinus massage, eyeball compression, and head-up tilt test in patients with syncope of uncertain origin and in healthy control subjectsAmerican Heart Journal, 1991
- Carotid Sinus Syndrome—Clinical Characteristics in Elderly PatientsAge and Ageing, 1991