Novel pathways for implantation and establishment and maintenance of pregnancy in mammals
Top Cited Papers
Open Access
- 30 October 2009
- journal article
- review article
- Published by Oxford University Press (OUP) in Molecular Human Reproduction
- Vol. 16 (3), 135-152
- https://doi.org/10.1093/molehr/gap095
Abstract
Uterine receptivity to implantation varies among species, and involves changes in expression of genes that are coordinate with attachment of trophectoderm to uterine lumenal and superficial glandular epithelia, modification of phenotype of uterine stromal cells, silencing of receptors for progesterone and estrogen, suppression of genes for immune recognition, alterations in membrane permeability to enhance conceptus-maternal exchange of factors, angiogenesis and vasculogenesis, increased vascularity of the endometrium, activation of genes for transport of nutrients into the uterine lumen, and enhanced signaling for pregnancy recognition. Differential expression of genes by uterine epithelial and stromal cells in response to progesterone, glucocorticoids, prostaglandins and interferons may influence uterine receptivity to implantation in mammals. Uterine receptivity to implantation is progesterone-dependent; however, implantation is preceded by loss of expression of receptors for progesterone (PGR) so that progesterone most likely acts via PGR-positive stromal cells throughout pregnancy. Endogenous retroviruses expressed by the uterus and/or blastocyst also affect implantation and placentation in various species. Understanding the roles of the variety of hormones, growth factors and endogenous retroviral proteins in uterine receptivity for implantation is essential to enhancing reproductive health and fertility in humans and domestic animals.Keywords
This publication has 152 references indexed in Scilit:
- Arginine metabolism and nutrition in growth, health and diseaseAmino Acids, 2008
- Tensegrity-based mechanosensing from macro to microProgress in Biophysics and Molecular Biology, 2008
- Expression of progesterone receptor membrane component 1 and its partner serpine 1 mRNA binding protein in uterine and placental tissues of the mouse and humanMolecular and Cellular Endocrinology, 2008
- Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteinsOncogene, 2008
- Functional atlas of the integrin adhesomeNature, 2007
- Expression of L-selectin ligand MECA-79 as a predictive marker of human uterine receptivityJournal of Assisted Reproduction and Genetics, 2007
- The role of chorionic gonadotropin and Notch1 in implantationJournal of Assisted Reproduction and Genetics, 2007
- Targeting sphingosine-1-phosphate for cancer therapyBritish Journal of Cancer, 2006
- Endogenous retroviruses regulate periimplantation placental growth and differentiationProceedings of the National Academy of Sciences of the United States of America, 2006
- mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth MachineryCell, 2002