Immunohistochemical distribution of c‐erbB‐2 in infiltrating and in situ breast cancer

Abstract

An immunohistochemical study of c‐erbB‐2 expression was performed on invasive and in situ breast cancer. Strong membrane staining was seen in 16% of the infiltrating ductal carcinomas and 44% of the in situ lesions. c‐erbB‐2 was over‐expressed in ductal rather than lobular tumours. Our results indicate that a small sub‐group of breast carcinomas are associated with over‐expression of this oncogene which may define an important subgroup of in situ and infiltrating ductal carcinomas.