Probiotics and the gut microbiota in intestinal health and disease
- 27 July 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Gastroenterology & Hepatology
- Vol. 7 (9), 503-514
- https://doi.org/10.1038/nrgastro.2010.117
Abstract
The use of probiotics is increasing in popularity for both the prevention and treatment of a variety of diseases; however, the specific immune and physiological effects of probiotics in health and disease have not been fully elucidated. This Review considers recent advances in clinical trials of probiotics for intestinal disorders. An overview ofin vitro and in vivoresearch related to potential mechanisms of action of various probiotic formulations is also considered. The use of probiotics is increasing in popularity for both the prevention and treatment of a variety of diseases. While a growing number of well-conducted, prospective, randomized, controlled, clinical trials are emerging and investigations of underlying mechanisms of action are being undertaken, questions remain with respect to the specific immune and physiological effects of probiotics in health and disease. This Review considers recent advances in clinical trials of probiotics for intestinal disorders in both adult and pediatric populations. An overview of recent in vitro and in vivo research related to potential mechanisms of action of various probiotic formulations is also considered.Keywords
This publication has 126 references indexed in Scilit:
- Metagenomic analyses reveal antibiotic-induced temporal and spatial changes in intestinal microbiota with associated alterations in immune cell homeostasisMucosal Immunology, 2010
- Generation of regulatory dendritic cells and CD4 + Foxp3 + T cells by probiotics administration suppresses immune disordersProceedings of the National Academy of Sciences of the United States of America, 2010
- Probiotics Prevent Death Caused byCitrobacter rodentiumInfection in Neonatal MiceThe Journal of Infectious Diseases, 2010
- Probiotics promote gut health through stimulation of epithelial innate immunityProceedings of the National Academy of Sciences of the United States of America, 2009
- The gut microbiota shapes intestinal immune responses during health and diseaseNature Reviews Immunology, 2009
- 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitisThe ISME Journal, 2009
- S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functionsProceedings of the National Academy of Sciences of the United States of America, 2008
- A core gut microbiome in obese and lean twinsNature, 2008
- Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patientsProceedings of the National Academy of Sciences of the United States of America, 2008
- Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118Proceedings of the National Academy of Sciences of the United States of America, 2007