Primary structure and transmembrane orientation of the murine anion exchange protein
- 1 July 1985
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 316 (6025), 234-238
- https://doi.org/10.1038/316234a0
Abstract
The amino-acid sequence of murine band 3, deduced from the nucleotide sequence of a complementary DNA clone, confirms that this integral membrane glycoprotein is composed of 2 major structural domains which correlate with its dual functions as the anchor for the erythrocyte cytoskeleton and as a plasma membrane anion antiporter. This latter activity resides within a highly hydrophobic domain that crosses the plasma membrane at least 12 times.Keywords
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