Uterine Gestational Choriocarcinoma Developing After a Long Latent Period in a Postmenopausal Woman: The Value of DNA Polymorphism Studies
- 1 April 2008
- journal article
- case report
- Published by SAGE Publications in International Journal of Surgical Pathology
- Vol. 16 (2), 226-229
- https://doi.org/10.1177/1066896907307038
Abstract
This article reports a uterine gestational choriocarcinoma arising in a 57-year-old woman with a long latent period of 22 years from the last known pregnancy. Diagnosis was made on an endometrial biopsy specimen, and given the age of the patient, the long latent period, and the limited sample, trophoblastic differentiation within an endometrial carcinoma was considered. The results of DNA polymorphism studies illustrated both paternal and maternal alleles within the tumor in equal amounts, confirming the neoplasm to be gestational in origin and to have originated from a nonmolar gestation. The report discusses the value of DNA polymorphism studies in distinguishing gestational from nongestational choriocarcinoma and from trophoblastic differentiation within a carcinoma.Keywords
This publication has 19 references indexed in Scilit:
- Primary gestational choriocarcinoma of the uterine cervix. Report of a case and review of the literatureInternational Journal of Gynecologic Cancer, 2007
- Serous Carcinoma of the Endometrium with Choriocarcinomatous DifferentiationInternational Journal of Gynecological Pathology, 2006
- Extrauterine choriocarcinoma of the greater omentum after tubal pregnancy: case reportInternational Journal of Gynecologic Cancer, 2006
- Persistent gestational trophoblastic disease is rarely, if ever, derived from non-molar first-trimester miscarriageMedical Hypotheses, 2005
- Histopathological Diagnosis of Partial and Complete Hydatidiform Mole in the First Trimester of PregnancyPediatric and Developmental Pathology, 2003
- Coexistent Choriocarcinoma and Malignant Mixed Mesodermal Tumor of the UterusGynecologic Oncology, 2000
- Endometrial Adenocarcinoma with Trophoblastic DifferentiationGynecologic Oncology, 1998
- Endometrial Adenocarcinoma with Choriocarcinomatous Differentiation in an Elderly Virginal WomanInternational Journal of Gynecological Pathology, 1995
- Primary endodermal sinus tumor of the endometrium. A clinicopathologic, immunocytochemical, and ultrastructural studyCancer, 1990
- CHORIOCARCINOMA INCIDENCE IN THE UNITED STATESAmerican Journal of Epidemiology, 1986