Delayed differentiation of potent effector CD8 + T cells reducing viremia and reservoir seeding in acute HIV infection
- 15 February 2017
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Translational Medicine
- Vol. 9 (377)
- https://doi.org/10.1126/scitranslmed.aag1809
Abstract
Potent CD8 + T cells endowed with effector functions able to kill HIV-producing cells and reduce the seeding of the HIV reservoir are only detected at peak viremia in acute HIV infection.Keywords
Funding Information
- U.S. Department of Defense (award296693)
- National Institute of Allergy and Infectious Diseases (award296694)
This publication has 68 references indexed in Scilit:
- A novel acute HIV infection staging system based on 4thgeneration immunoassayRetrovirology, 2013
- Cytomegalovirus Vectors Violate CD8 + T Cell Epitope Recognition ParadigmsScience, 2013
- Initial HIV-1 Antigen-Specific CD8 + T Cells in Acute HIV-1 Infection Inhibit Transmitted/Founder Virus ReplicationJournal of Virology, 2012
- Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus ReactivationImmunity, 2012
- Profound early control of highly pathogenic SIV by an effector memory T-cell vaccineNature, 2011
- Defective Human Immunodeficiency Virus-Specific CD8 + T-Cell Polyfunctionality, Proliferation, and Cytotoxicity Are Not Restored by Antiretroviral TherapyJournal of Virology, 2009
- Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus InfectionsJournal of Virology, 2009
- Visualizing Antigen-Specific and Infected Cells in Situ Predicts Outcomes in Early Viral InfectionScience, 2009
- Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infectionNature Immunology, 2008
- Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infectionThe Journal of Experimental Medicine, 2008