Host-Gut Microbiota Metabolic Interactions
Top Cited Papers
- 8 June 2012
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 336 (6086), 1262-1267
- https://doi.org/10.1126/science.1223813
Abstract
The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.Keywords
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