Cellular Hypersensitivity to Basic Myelin (P2) Protein in the Guillain-Barré Syndrome
- 1 February 1975
- journal article
- research article
- Published by Cambridge University Press (CUP) in Canadian Journal of Neurological Sciences
- Vol. 2 (2), 87-90
- https://doi.org/10.1017/s0317167100020059
Abstract
SUMMARY: Lymphocytes of 29 subjects were assayed for MIF production in response to P2 peripheral nerve protein, crude human peripheral nerve and human central nervous system Al basic myelin protein. Seven were performed in normal control subjects, 12 in Guillain-Barré patients (GB), 5 with other polyneuropathies and 5 in patients with multiple sclerosis (MS). Only GB patients with acute illness produced MIF in response to neuritogenic P2 protein and crude human nerve. Two MS patients in the acute phase of an exacerbation and one GB patient produced MIF in Response to Al protein. The results of this study demonstrate cellular hypersensitivity to a neuritogenic constituent in peripheral nervous tissue and support the concept that this may be important in the pathogenesis of GB.Keywords
This publication has 11 references indexed in Scilit:
- Cellular Hypersensitivity to Basic Myelin (A1) Protein and Clinical Multiple SclerosisNew England Journal of Medicine, 1974
- Experimental allergic neuritis: a new experimental approachJournal of Neurology, Neurosurgery & Psychiatry, 1973
- Cell-Mediated Hypersensitivity to Neural AntigensArchives of Neurology, 1972
- ELECTROPHORETIC STUDIES OF BASIC PROTEINS CAPABLE OF INDUCING EXPERIMENTAL ALLERGIC NEURITISJournal of Neurochemistry, 1972
- The Guillain-Barré Syndrome and Multiple SclerosisNew England Journal of Medicine, 1971
- LYMPHOCYTE TRANSFORMATION IN THE GUILLAIN-BARRÉ SYNDROMEBrain, 1971
- THE INFLAMMATORY LESION IN IDIOPATHIC POLYNEURITISMedicine, 1969
- Antibody response to central and peripheral nerve antigens in rat and guinea-pigJournal of Neurology, Neurosurgery & Psychiatry, 1965
- ALLERGIC NEURITIS: AN EXPERIMENTAL DISEASE OF RABBITS INDUCED BY THE INJECTION OF PERIPHERAL NERVOUS TISSUE AND ADJUVANTSThe Journal of Experimental Medicine, 1955
- THE LANDRY-GUILLAIN-BARR?? SYNDROMEMedicine, 1949