Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer.
Open Access
- 1 July 1987
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 166 (1), 219-234
- https://doi.org/10.1084/jem.166.1.219
Abstract
Primate bone marrow cells were infected with a retroviral vector carrying the genes for human adenosine deaminase (h-ADA) and bacterial neomycin resistance (neor). The infected cells were infused back into the lethally irradiated donor animals. Several monkeys fully reconstituted and were shown to express the h-ADA and neor genes at low levels in their recirculating hematopoietic cells for short periods of time.Keywords
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