Sex differences in microglial colonization of the developing rat brain
Open Access
- 19 December 2011
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 120 (6), 948-963
- https://doi.org/10.1111/j.1471-4159.2011.07630.x
Abstract
J. Neurochem. (2012) 120, 948–963. Abstract Microglia are the resident immune cells within the brain and their production of immune molecules such as cytokines and chemokines is critical for the processes of normal brain development including neurogenesis, axonal migration, synapse formation, and programmed cell death. Notably, sex differences exist in many of these processes throughout brain development; however, it is unknown whether a sex difference concurrently exists in the colonization, number, or morphology of microglia within the developing brain. We demonstrate for the first time that the number and morphology of microglia throughout development is dependent upon the sex and age of the individual, as well as the brain region of interest. Males have overall more microglia early in postnatal development [postnatal day (P) 4], whereas females have more microglia with an activated/amoeboid morphology later in development, as juveniles and adults (P30–60). Finally, gene expression of a large number of cytokines, chemokines and their receptors shifts dramatically over development, and is highly dependent upon sex. Taken together, these data warrant further research into the role that sex‐dependent mechanisms may play in microglial colonization, number, and function, and their potential contribution to neural development, function, or potential dysfunction.Keywords
This publication has 54 references indexed in Scilit:
- Microglia and Memory: Modulation by Early-Life InfectionJournal of Neuroscience, 2011
- A Lifespan Approach to Neuroinflammatory and Cognitive Disorders: A Critical Role for GliaJournal of Neuroimmune Pharmacology, 2011
- Sex differences in the inflammatory response of primary astrocytes to lipopolysaccharideBiology of Sex Differences, 2011
- Sex difference in cell proliferation in developing rat amygdala mediated by endocannabinoids has implications for social behaviorProceedings of the National Academy of Sciences of the United States of America, 2010
- β‐Chemokine production by neural and glial progenitor cells is enhanced by HIV‐1 Tat: effects on microglial migrationJournal of Neurochemistry, 2010
- Novel roles for immune molecules in neural development: implications for neurodevelopmental disordersFrontiers in Synaptic Neuroscience, 2010
- Sex differences and laterality in astrocyte number and complexity in the adult rat medial amygdalaJournal of Comparative Neurology, 2008
- Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessmentExpert Opinion on Drug Metabolism & Toxicology, 2008
- Steroid‐induced sexual differentiation of the developing brain: multiple pathways, one goalJournal of Neurochemistry, 2008
- Viewing chemokines as a third major system of communication in the brainThe AAPS Journal, 2005