Primary Intraspinal Primitive Neuroectodermal Tumor
- 1 April 2002
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in American Journal of Clinical Oncology
- Vol. 25 (2), 135-139
- https://doi.org/10.1097/00000421-200204000-00007
Abstract
Primary spinal primitive neuroectodermal tumor (PNET) is a rare condition, 18 cases of which have been reported in the literature. In general, this tumor is treated with surgery followed by radiotherapy and chemotherapy, but prognosis is still poor. An 18-year-old female patient with an intradural, extramedullary mass at L3-L5 levels is presented in this report. This is the first female patient with primary spinal PNET at lumbar region, second patient with spinal nerve root origin, and third one with intradural, extramedullary localization ever reported in the literature. After surgery, she was treated with craniospinal radiotherapy and four cycles of combination chemotherapy regimen consisting of vincristine, cyclophosphamide, doxorubicin alternated with ifosfamide, and VP-16. Currently, she is asymptomatic and alive at 25 months. The histopathologic, radiologic, and clinical findings of the patient are presented and relevant literature is reviewed.Keywords
This publication has 17 references indexed in Scilit:
- Primary Intramedullary Primitive Neuroectodermal Tumor of the Spinal Cord: Case Report and Review of the LiteratureNeurosurgery, 1997
- Primitive neuroectodermal tumour of the cauda equinaNeuroradiology, 1994
- The New WHO Classification of Brain TumoursBrain Pathology, 1993
- Primary Primitive Neuroectodermal Tumor of the Spinal Cord Associated with Neural Tube DefectPediatric Neurosurgery, 1989
- Primary spinal medulloblastomas?Neurosurgical Review, 1988
- Primitive neuroectodermal tumors of the central nervous systemHuman Pathology, 1983
- PRESIDENTIAL ADDRESSJournal of Neuropathology and Experimental Neurology, 1983
- The development of experimental brain tumours a sequential light and electron microscope study of the subependymal plateActa Neuropathologica, 1979
- Primitive neuroectodermal tumors of the brain in childrenCancer, 1973
- Metastasizing Neuroectodermal Tumors of the Central Nervous SystemJournal of Neurosurgery, 1969