A Specific Action of Estradiol on Enzymes Involved in Testicular Steroidogenesis

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Abstract
LH-Stimulated steroid production was studied in vitro in Leydig cells isolated from testes of 26, 32, 44, 54, and 64-day-old rats treated with estradiol implants. Five days after implantation of estradiol, the maximal testosterone production was decreased in 32, 44, 52, and 64-day-old rats, while maximal Δ5-pregnenolone production was not changed. In 26-day-old rats, however, production rates of both testosterone and Δ5-pregnenolone were decreased. The estradiol effect on testosterone production could be observed 48 h after implantation.