Prognostic Significance of Nucleolar Organizer Region (AgNOR) in Renal Cell Carcinoma
- 1 October 1995
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Urology
- Vol. 154 (4), 1522-1526
- https://doi.org/10.1016/s0022-5347(01)66921-0
Abstract
Evaluation of prognostic significance of nucleolar organizer regions (NORs) in renal cell carcinoma (RCC). Nuclear organizer regions were quantified in a series of 59 cases of RCC by the silver colloid method, and the NOR index was obtained from the ratio between mean NOR counts in each neoplastic nucleus and in normal nucleus. The patients were staged pathologically and divided into 2 groups by average NOR index of all cases, which was 0.76. Correlations between the NOR index and other parameters were statistically analyzed, and the prognostic value of the NOR index was also examined. The NOR indices from each group were correlated with the survival curve. In low stage tumors (pT1 or 2 N0M0), the low NOR index group had a survival rate of almost 100 per cent while in those patients with higher NOR indices, there was a significantly increased mortality (p less than 0.01). In patients presenting with high stage tumors (excluding pT1 and 2 NOMO), the survival rate was significantly improved in those patients with a low NOR index (p less than 0.01). On the other hand, the patients with a low NOR index have a better prognosis than those with a high NOR index within each tumor grade (p less than 0.01). Statistical analysis by the log rank test indicated NORs to be a significant predictor of survival over the whole series within low and high pathological stages and within each tumor grade. Analysis of the data with Cox's proportional hazard model showed that NOR index had a stronger hazard ratio than grade or stage of tumor (p = 0.0005). Our study has demonstrated that NOR index is a new prognostic indicator for patients with RCC (p = 0.0005).Keywords
This publication has 15 references indexed in Scilit:
- Silver‐binding nucleolar organizer regions (AgNORs) in benign and malignant breast lesions: Correlations with ploidy and growth phase by DNA flow cytometryThe Journal of Pathology, 1989
- Nucleolar organizer regions as diagnostic discriminants for malignancyThe Journal of Pathology, 1988
- Renal cell carcinoma.Prognostic significance of morphologic parameters in 121 casesCancer, 1988
- Nucleolar organizer regions in lymphomasThe Journal of Pathology, 1987
- Improvement in the staining and in the visualization of the argyrophilic proteins of the nucleolar organizer region at the optical levelJournal of Molecular Histology, 1986
- The Challenges of Renal AdenocarcinomaSurgical Clinics of North America, 1982
- Renal Cell Carcinoma: Long-Term Survival and Late RecurrenceJournal of Urology, 1981
- Ultrastructural localization of Ag-NOR stained proteins in the nucleolus during the cell cycle and in other nucleolar structuresChromosoma, 1980
- The Results of Radical Nephrectomy for Renal Cell CarcinomaJournal of Urology, 1969
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958