Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy
Open Access
- 24 November 2009
- journal article
- review article
- Published by Springer Science and Business Media LLC in British Journal of Cancer
- Vol. 102 (1), 1-7
- https://doi.org/10.1038/sj.bjc.6605457
Abstract
Developing rational targeted cancer drugs requires the implementation of pharmacodynamic (PD), preferably non-invasive, biomarkers to aid response assessment and patient follow-up. Magnetic resonance spectroscopy (MRS) allows the non-invasive study of tumour metabolism. We describe the MRS-detectable PD biomarkers resulting from the action of targeted therapeutics, and discuss their biological significance and future translation into clinical use.Keywords
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