CD‐34 selected hematopoetic stem cell transplantation from HLA identical family members for fanconi anemia

Abstract
Hematopoetic stem cell transplantation, even from an HLA 6/6 identical family member is associated with an increased frequency of complication in fanconi anemia (FA). The increased susceptibility for chromosomal breaks has been suggested as a contributory factor for increased risk of toxicity, graft versus host disease (GVHD) and increased incidence of post‐transplant solid tumors. Therefore, non‐irradiation based preparative regimens usually containing fludarabine and T‐cell depletion of HLA geno‐identical bone marrow cells have increasingly been used in patients with FA. Here, we report three children with FA who underwent CD‐34 selected HSCT from HLA‐identical family donors with reduced intensity fludarabine‐based regimen. Pediatr Blood Cancer 2008;50:1065–1067.

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