Direct Cross‐Coupling of C-H Bonds with Grignard Reagents through Cobalt Catalysis
- 22 December 2010
- journal article
- research article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 50 (5), 1109-1113
- https://doi.org/10.1002/anie.201005394
Abstract
Go go Grignard! The first highly regioselective, cobalt‐catalyzed CH transformation of benzo[h]quinoline and phenylpyridine derivatives with Grignard reagents at room temperature has been achieved (see scheme). Both aryl and alkyl Grignard reagents showed significant reactivity.Keywords
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