Lung Diseases in Patients With Common Variable Immunodeficiency
- 1 September 2006
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Computer Assisted Tomography
- Vol. 30 (5), 828-838
- https://doi.org/10.1097/01.rct.0000228163.08968.26
Abstract
To evaluate chest radiographic and computed tomographic (CT) findings of lung disease related to common variable immunodeficiency. Thirty-five chest radiographs and 30 CT scans of 46 patients were assessed. Lung parenchymal abnormalities that were evaluated included airspace consolidation, ground-glass attenuation, nodules, bronchiectasis, and air trapping. On CT, ground-glass attenuation and nodules were the most frequent findings, observed in 60% (n = 18/30) and 83% (n = 25/30), respectively. Three major CT patterns were identified: airway disease (n = 13), nodules (n = 8), and parenchymal opacification (n = 6). All 13 patients with airway disease showed centrilobular opacities. One patient with peribronchial nodules showed lymphoid interstitial pneumonia, and 1 with randomly distributed nodules showed noncaseating granulomas. Patients with a CT pattern of parenchymal opacification showed lower lung predominance; surgical biopsies showed organizing pneumonia in 1 patient and lymphoid interstitial pneumonia with nonnecrotizing granulomas in another. Common variable immunodeficiency is associated with 3 major CT patterns: airway disease, nodules, and parenchymal opacification.Keywords
This publication has 26 references indexed in Scilit:
- Organizing Pneumonia Related to Common Variable ImmunodeficiencyRespiration, 2000
- Sarcoidosis and Common Variable ImmunodeficiencyRespiration, 2000
- Lymphoid interstitial pneumonitis associated with common variable hypogammaglobulinaemia treated with cyclosporin AThorax, 2000
- Granulomatous Interstitial Pneumonitis in Association With Primary HypogammaglobulinemiaJournal of Thoracic Imaging, 1999
- Chest high resolution CT in adults with primary humoral immunodeficiencyThe British Journal of Radiology, 1996
- Report of 8 Cases and Review of the LiteratureMedicine, 1996
- CT findings in bronchiectasis: limited value in distinguishing between idiopathic and specific types.American Journal of Roentgenology, 1995
- Retrospective analysis of the incidence of pulmonary disease in hypogammaglobulinemiaJournal of Allergy and Clinical Immunology, 1991
- Common variable hypogammaglobulinemia with T-cell nodular lymphoid interstitial pneumonitis and B-cell nodular lymphoid hyperplasia: Different lymphocyte populations with a similar response to prednisone therapyJournal of Allergy and Clinical Immunology, 1982
- Pulmonary manifestations of hypogammaglobulinaemia.Thorax, 1978