Review: Structure and Function of IRF-7
- 1 January 2002
- journal article
- review article
- Published by Mary Ann Liebert Inc in Journal of Interferon & Cytokine Research
- Vol. 22 (1), 95-101
- https://doi.org/10.1089/107999002753452700
Abstract
Interferon (IFN) regulatory factors (IRF) are a family of transcription factors with multiple functions. IRF-7 was initially cloned within the biologic context of Epstein-Barr virus (EBV) latency and discovered to have an intimate relation with the EBV primary oncogenic protein, latent membrane protein-1 (LMP-1). EBV regulates and uses IRF-7 as a secondary mediator for several target genes involved in latency and immune regulation. Other than its functions in EBV latency, IRF-7 has been identified as one of the major players in virally induced IFN production that is central to innate immunity. Thus, IRF-7 plays important roles in a variety of biologic systems.Keywords
This publication has 55 references indexed in Scilit:
- Interferon regulatory factor 7: a key cellular mediator of LMP-1 in EBV latency and transformationSeminars in Cancer Biology, 2001
- Intracellular Signaling Molecules Activated by Epstein-Barr Virus for Induction of Interferon Regulatory Factor 7Journal of Virology, 2001
- Direct and Indirect Regulation of Cytokine and Cell Cycle Proteins by EBNA-2 during Epstein-Barr Virus InfectionJournal of Virology, 2001
- IRF3 and IRF7 Phosphorylation in Virus-infected Cells Does Not Require Double-stranded RNA-dependent Protein Kinase R or IκB Kinase but Is Blocked by Vaccinia Virus E3L ProteinOnline Journal of Public Health Informatics, 2001
- Interferon Regulatory Factor 7 Mediates Activation of Tap-2 by Epstein-Barr Virus Latent Membrane Protein 1Journal of Virology, 2001
- Phosphorylation-Induced Dimerization of Interferon Regulatory Factor 7 Unmasks DNA Binding and a Bipartite Transactivation DomainMolecular and Cellular Biology, 2000
- Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein‐Barr virus latent membrane protein‐1: coordinate up‐regulation of peptide transporters and HLA‐class I antigen expressionEuropean Journal of Immunology, 1995
- Suppression of c-myc or fosB-induced cell transformation by the transcription factor IRF-1Cancer Letters, 1994
- Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elementsCell, 1988
- An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cellsCell, 1985