The secret life of kinases: functions beyond catalysis
Open Access
- 1 January 2011
- journal article
- Published by Springer Science and Business Media LLC in Cell Communication and Signaling
- Vol. 9 (1), 23
- https://doi.org/10.1186/1478-811x-9-23
Abstract
Protein phosphorylation participates in the regulation of all fundamental biological processes, and protein kinases have been intensively studied. However, while the focus was on catalytic activities, accumulating evidence suggests that non-catalytic properties of protein kinases are essential, and in some cases even sufficient for their functions. These non-catalytic functions include the scaffolding of protein complexes, the competition for protein interactions, allosteric effects on other enzymes, subcellular targeting, and DNA binding. This rich repertoire often is used to coordinate phosphorylation events and enhance the specificity of substrate phosphorylation, but also can adopt functions that do not rely on kinase activity. Here, we discuss such kinase independent functions of protein and lipid kinases focussing on kinases that play a role in the regulation of cell proliferation, differentiation, apoptosis, and motilityKeywords
This publication has 98 references indexed in Scilit:
- Myogenic Differentiation Is Dependent on Both the Kinase Function and the N-terminal Sequence of Mammalian Target of RapamycinOnline Journal of Public Health Informatics, 2002
- The Nonreceptor Tyrosine Kinase ACK2, a Specific Target for Cdc42 and a Negative Regulator of Cell Growth and Focal Adhesion ComplexesOnline Journal of Public Health Informatics, 2001
- The Mammalian Target of Rapamycin Regulates C2C12 Myogenesis via a Kinase-independent MechanismOnline Journal of Public Health Informatics, 2001
- Stimulation of Mitogenic Pathways through Kinase-Impaired Mutants of the Epidermal Growth Factor ReceptorExperimental Cell Research, 2001
- Regulation of Ras Signaling Specificity by Protein Kinase CMolecular and Cellular Biology, 2001
- ASK1-Signaling Promotes c-Myc Protein Stability during ApoptosisBiochemical and Biophysical Research Communications, 2001
- Divergent Signaling Pathways Link Focal Adhesion Kinase to Mitogen-activated Protein Kinase CascadesOnline Journal of Public Health Informatics, 1999
- Human p21-activated kinase (Pak1) regulates actin organization in mammalian cellsCurrent Biology, 1997
- c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism.Genes & Development, 1995
- A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localizationCell, 1990