Lysosomes

Abstract

Labilization and Stabilization of LysosomesSince the membranes bounding lysosomes appeared to resemble the unit membranes that surround erythrocytes, and since these have been assumed to be lipoprotein in nature, it was reasonable to expect that a number of membrane-active drugs, vitamins, toxins or other substances might act to labilize or stabilize the surface of lysosomes. Table 2 lists some of the agents that rupture lysosomes in vitro. It will soon be appreciated that most, if not all, of these are also hemolytic^{117 , 118}; many affect mitochondria^{85, 119} as well. Most of the fat-soluble steroids and hormones exert their effects at concentrations of . . .