Myelin proteins in aging human brain
- 1 February 1991
- journal article
- research article
- Published by Springer Science and Business Media LLC in Molecular and Chemical Neuropathology
- Vol. 14 (1), 1-10
- https://doi.org/10.1007/bf03160993
Abstract
Autopsy material of 13 persons who died between 70 and 89 yrs old and of patients who died between 27 and 44 yrs old was studied. White matter of temporal, parietal, and occipital lobes was investigated using histological and biochemical methods. According to results of neuropathological studies, the material of aged patients was divided into two subgroups: (a) brains with vascular changes only and (b) patients with senile atrophy of Alzheimer type. Chemical changes found in all studied brain lobes included a mild decrease in Wolfgram protein content with reciprocal increase in large basic protein content, together with a marked decrease in myelin yield. The abovementioned chemical changes were almost identical whether they were only vascular changes or whether senile atrophy of Alzheimer type was also present. It seems, therefore, that the degeneration of vessels is the decisive factor in the pathogenetic mechanism of myelin lesions in the aged brain.Keywords
This publication has 8 references indexed in Scilit:
- Qualitative and Quantitative Comparison of Brain Proteins in Alzheimer᾿s DiseaseBiological Chemistry Hoppe-Seyler, 1989
- NON-CHOLINERGIC NEUROTRANSMITTER ABNORMALITIES IN ALZHEIMER'S DISEASEBritish Medical Bulletin, 1986
- Proteins of MyelinPublished by Springer Science and Business Media LLC ,1984
- Isolation and Characterization of MyelinPublished by Springer Science and Business Media LLC ,1984
- Studies on the Wolfgram High Molecular Weight CNS Myelin Proteins: Relationship to 2′,3′‐Cyclic Nucleotide 3′‐PhosphodiesteraseJournal of Neurochemistry, 1980
- Comparison of 2′,3′‐Cyclic Nucleotide 3′‐Phosphodiesterase and the Major Component of Wolfgram Protein W1Journal of Neurochemistry, 1980
- MYELINATION IN RAT BRAIN: METHOD OF MYELIN ISOLATION1Journal of Neurochemistry, 1973
- Composition and Metabolism of Myelin Phosphoglycerides During Maturation and AgingProgress in brain research, 1973