Design and Utility of Metal/Metal Oxide Nanoparticles Mediated by Thioether End-Functionalized Polymeric Ligands
Open Access
- 21 April 2016
- Vol. 8 (4), 156
- https://doi.org/10.3390/polym8040156
Abstract
The past few decades have witnessed significant advances in the development of functionalized metal/metal oxide nanoparticles including those of inorganic noble metals and magnetic materials stabilized by various polymeric ligands. Recent applications of such functionalized nanoparticles, including those in bio-imaging, sensing, catalysis, drug delivery, and other biomedical applications have triggered the need for their facile and reproducible preparation with a better control over their size, shape, and surface chemistry. In this perspective, the multidentate polymer ligands containing functional groups like thiol, thioether, and ester are important surface ligands for designing and synthesizing stable nanoparticles (NPs) of metals or their oxides with reproducibility and high yield. These ligands have offered an unprecedented control over the particle size of both nanoparticles and nanoclusters with enhanced colloidal stability, having tunable solubility in aqueous and organic media, and tunable optical, magnetic, and fluorescent properties. This review summarizes the synthetic methodologies and stability of nanoparticles and fluorescent nanoclusters of metals (Au, Ag, Cu, Pt, and other transition metal oxides) prepared by using thioether based ligands and highlights their applications in bio-imaging, sensing, drug delivery, magnetic resonance imaging (MRI), and catalysis. The future applications of fluorescent metal NPs like thermal gradient optical imaging, single molecule optoelectronics, sensors, and optical components of the detector are also envisaged.Keywords
Funding Information
- National Natural Science Foundation of China (21474033, 51273074, 51173058)
This publication has 127 references indexed in Scilit:
- Polyethyleneimine-modified iron oxide nanoparticles for brain tumor drug delivery using magnetic targeting and intra-carotid administrationBiomaterials, 2010
- PEG-Mediated Synthesis of Highly Dispersive Multifunctional Superparamagnetic Nanoparticles: Their Physicochemical Properties and Function In VivoACS Nano, 2010
- Tailored composite polymer-metal nanoparticles by miniemulsion polymerization and thiol-ene functionalizationJournal of Polymer Science Part A: Polymer Chemistry, 2010
- Carbon Dots as Nontoxic and High-Performance Fluorescence Imaging AgentsThe Journal of Physical Chemistry C, 2009
- Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveatsNanomedicine, 2008
- Synthesis of 64Cu-Labeled Magnetic Nanoparticles for Multimodal ImagingBioconjugate Chemistry, 2008
- Synthesis and characterization of PVP-coated large core iron oxide nanoparticles as an MRI contrast agentNanotechnology, 2008
- Highly Fluorescent Noble-Metal Quantum DotsAnnual Review of Physical Chemistry, 2007
- Some recent advances in nanostructure preparation from gold and silver particles: a short topical reviewColloids and Surfaces A: Physicochemical and Engineering Aspects, 2002
- Practical preparation of anionic mercapto ligand-stabilized gold nanoparticles and their immobilizationColloids and Surfaces A: Physicochemical and Engineering Aspects, 1999