Prospective Multicenter Study of Children With Bronchiolitis Requiring Mechanical Ventilation
- 1 September 2012
- journal article
- research article
- Published by American Academy of Pediatrics (AAP) in PEDIATRICS
- Vol. 130 (3), e492-e500
- https://doi.org/10.1542/peds.2012-0444
Abstract
OBJECTIVE: To identify factors associated with continuous positive airway pressure (CPAP) and/or intubation for children with bronchiolitis. METHODS: We performed a 16-center, prospective cohort study of hospitalized children aged RESULTS: There were 161 children who required CPAP and/or intubation. The median age of the overall cohort was 4 months; 59% were male; 61% white, 24% black, and 36% Hispanic. In the multivariable model predicting CPAP/intubation, the significant factors were: age CONCLUSIONS: In this multicenter study of children hospitalized with bronchiolitis, we identified several demographic, historical, and clinical factors that predicted the use of CPAP and/or intubation, including children born to mothers who smoked during pregnancy. We also identified a novel subgroup of children who required mechanical respiratory support <1 day after respiratory symptoms began.This publication has 66 references indexed in Scilit:
- Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: systematic review and meta-analysisRespiratory Research, 2011
- Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus InfectionCell, 2011
- Cigarette Smoke Alters Respiratory Syncytial Virus–Induced Apoptosis and ReplicationAmerican Journal of Respiratory Cell and Molecular Biology, 2009
- The severity-dependent relationship of infant bronchiolitis on the risk and morbidity of early childhood asthmaJournal of Allergy and Clinical Immunology, 2009
- Evaluation of Three Real-Time PCR Assays for Detection of Mycoplasma pneumoniae in an Outbreak InvestigationJournal of Clinical Microbiology, 2008
- Increasing Burden and Risk Factors for Bronchiolitis-Related Medical Visits in Infants Enrolled in a State Health Care Insurance PlanPEDIATRICS, 2008
- Identifying Hospitalized Infants Who Have Bronchiolitis and Are at High Risk for ApneaAnnals of Emergency Medicine, 2006
- Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study of admission and management variation in patients hospitalized with respiratory syncytial viral lower respiratory tract infectionThe Journal of Pediatrics, 1996
- Variation in severity of respiratory syncytial virus infections with subtypeThe Journal of Pediatrics, 1990
- Endotracheal intubation of pediatric patients by paramedicsAnnals of Emergency Medicine, 1989