Measles outbreak in a vaccinated school population: epidemiology, chains of transmission and the role of vaccine failures.
- 1 April 1987
- journal article
- research article
- Published by American Public Health Association in American Journal of Public Health
- Vol. 77 (4), 434-438
- https://doi.org/10.2105/ajph.77.4.434
Abstract
An outbreak of measles occurred in a high school with a documented vaccination level of 98 per cent. Nineteen (70 per cent) of the cases were students who had histories of measles vaccination at 12 months of age or older and are therefore considered vaccine failures. Persons who were unimmunized or immunized at less than 12 months of age had substantially higher attack rates compared to those immunized on or after 12 months of age. Vaccine failures among apparently adequately vaccinated individuals were sources of infection for at least 48 per cent of the cases in the outbreak. There was no evidence to suggest that waning immunity was a contributing factor among the vaccine failures. Close contact with cases of measles in the high school, source or provider of vaccine, sharing common activities or classes with cases, and verification of the vaccination history were not significant risk factors in the outbreak. The outbreak subsided spontaneously after four generations of illness in the school and demonstrates that when measles is introduced in a highly vaccinated population, vaccine failures may play some role in transmission but that such transmission is not usually sustained.This publication has 22 references indexed in Scilit:
- Antibody response following measles-mumps-rubella vaccine under conditions of customary usePublished by American Medical Association (AMA) ,1983
- Further-Attenuated Measles Vaccine: Characteristics and UseClinical Infectious Diseases, 1983
- Follow-Up Surveillance for Antibody in Human Subjects following Live Attenuated Measles, Mumps, and Rubella Virus VaccinesExperimental Biology and Medicine, 1979
- Clinical Review : Measles Vaccine FailureClinical Pediatrics, 1979
- Epidemic Measles in a Highly Vaccinated PopulationNew England Journal of Medicine, 1977
- Present status of measles and rubella immunization in the United States: A medical progress reportThe Journal of Pediatrics, 1977
- Measles in children previously vaccinated against measlesPublished by American Medical Association (AMA) ,1971
- Development and evaluation of the Moraten measles virus vaccinePublished by American Medical Association (AMA) ,1968
- Extensive Clinical Evaluations of a Highly Attenuated Live Measles VaccinePublished by American Medical Association (AMA) ,1967
- Extensive clinical evaluations of a highly attenuated live measles vaccinePublished by American Medical Association (AMA) ,1967