The first six months of flight data from the Multiband Imaging Photometer for Spitzer (MIPS) were used to test MIPS reduction algorithms based on extensive preflight laboratory data and modeling. The underlying approach for the preflight algorithms has been found to be sound, but some modifications have improved the performance. The main changes are scan mirror dependent flat fields at 24 μm, hand processing to remove the time dependent stim flash latents and fast/slow response variations at 70 μm, and the use of asteroids and other sources instead of stars for flux calibration at 160 μm due to a blue "leak." The photometric accuracy of flux measurements is currently 5%, 10%, and 20% at 24, 70, and 160 μm, respectively. These numbers are expected to improve as more flight data are analyzed and data reduction algorithms refined.