Frequency of Infections Associated With Implanted Systems vs Cuffed, Tunneled Silastic Venous Catheters in Patients With Acute Leukemia
- 1 December 1991
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Pediatrics & Adolescent Medicine
- Vol. 145 (12), 1433-1438
- https://doi.org/10.1001/archpedi.1991.02160120101028
Abstract
• A total of 75 central venous catheters were used for prolonged chemotherapy in 39 children with acute lymphocytic leukemia and 21 patients with acute myelocytic leukemia. Infection rates were 2.2 per 1000 catheter days with the use of cuffed, tunneled, single-lumen Silastic catheters, 2.0 per 1000 catheter days with cuffed, tunneled, double-lumen Silastic catheters, and 0.5 per 1000 catheter days with the use of implanted venous access systems. Eighty-one percent of catheter sepsis episodes were successfully treated without removal of the catheter. All tunnel infections required withdrawal of the catheter for cure. The microorganisms were gram-positive bacteria in 15%, gram-negative bacteria in 7%, and fungi in 4%. Coagulase-negative staphylococci and Pseudomonas aeruginosa were the most commonly isolated organisms. Three of six fatal sepsis episodes were caused by disseminated fungal infections. We conclude that the use of intracorporeal venous catheter systems in patients with acute lymphocytic leukemia is associated with a lower infection rate than that with cuffed, tunneled Silastic single- or double-lumen catheters and that most septicemias can be cured with antimicrobial therapy without removal of the catheter. (AJDC. 1991;145:1433-1438)Keywords
This publication has 12 references indexed in Scilit:
- Prolonged venous access for chemotherapy by means of the hickman catheterCancer, 2006
- Gram-positive infections in granulocytopenic patients: an important issue?Journal of Antimicrobial Chemotherapy, 1988
- Is It Real or Is It a Contaminant? A Guide to the Interpretation of Blood Culture ResultsArchives of Pediatrics & Adolescent Medicine, 1987
- Implantable subcutaneous venous catheters.Archives of Disease in Childhood, 1986
- Adherence of Candida Species to Host Tissues and Plastic SurfacesClinical Infectious Diseases, 1986
- A totally implantable venous access system for long-term chemotherapy in childrenJournal of Pediatric Surgery, 1985
- Problems associated with indwelling central venous catheters.Archives of Disease in Childhood, 1985
- Hospital-acquired bloodstream infections with staphylococcus epidermidis: Review of 100 casesAmerican Journal Of Medicine, 1984
- Broviac central venous catheterization in infants and childrenThe American Journal of Surgery, 1983
- Leukocyte function in patients with leukemiaCancer, 1970