The use of lipid-based nanocarriers for targeted pain therapies
Open Access
- 1 January 2013
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Pharmacology
- Vol. 4, 143
- https://doi.org/10.3389/fphar.2013.00143
Abstract
Sustained delivery of analgesic agents at target sites remains a critical issue for effective pain management. The use of nanocarriers has been reported to facilitate effective delivery of these agents to target sites while minimising systemic toxicity. These include the use of biodegradable liposomal or polymeric carriers. Of these, liposomes present as an attractive delivery system due to their flexible physicochemical properties which allow easy manipulation in order to address different delivery considerations. Their favourable toxicity profiles and ease of large scale production also make their clinical use feasible. In this review, we will discuss the concept of using liposomes as a drug delivery carrier, their in vitro characteristics as well as in vivo behaviour. Current advances in the targeted liposomal delivery of analgesic agents and their impacts on the field of pain management will be presented.Keywords
This publication has 57 references indexed in Scilit:
- Cannabinoid derivate-loaded PLGA nanocarriers for oral administration: formulation, characterization, and cytotoxicity studiesInternational Journal of Nanomedicine, 2012
- Challenges in Development of Targeted Liposomal TherapeuticsThe AAPS Journal, 2012
- Mechanisms of peripheral immune-cell-mediated analgesia in inflammation: clinical and therapeutic implicationsTrends in Pharmacological Sciences, 2010
- Amphipathic weak acid glucocorticoid prodrugs remote‐loaded into sterically stabilized nanoliposomes evaluated in arthritic rats and in a Beagle dog: A novel approach to treating autoimmune arthritisArthritis & Rheumatism, 2007
- New Dosage Formulations for Targeted Delivery of Cyclo-Oxygenase-2 InhibitorsDrugs & Aging, 2007
- Analgesic effects of loperamide in bone cancer pain in micePharmacology Biochemistry and Behavior, 2005
- A Comparison of Depodur???, a Novel, Single-Dose Extended-Release Epidural Morphine, with Standard Epidural Morphine for Pain Relief After Lower Abdominal SurgeryAnesthesia & Analgesia, 2005
- Transendothelial Movement of Liposomes In Vitro Mediated by Cancer Cells, Neutrophils or HistamineJournal of Liposome Research, 2004
- Affinity liposomes in vivo: factors influencing target accumulationJournal of Molecular Recognition, 1996
- Use of liposome‐associated bupivacaine in a cancer pain syndromeAnaesthesia, 1996