Does eating particular diets alter the risk of age-related macular degeneration in users of the Age-Related Eye Disease Study supplements?
- 9 June 2009
- journal article
- research article
- Published by BMJ in British Journal of Ophthalmology
- Vol. 93 (9), 1241-1246
- https://doi.org/10.1136/bjo.2008.143412
Abstract
Background: Recent information suggests that the Age-Related Eye Disease Study (AREDS) supplement, enhanced intake of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), and reducing dietary glycaemic index (dGI) are protective against advanced age-related macular degeneration (AMD). Methods: Dietary information was collected at baseline, and fundus photograph grades were obtained during the 8-year trial period from 2924 eligible AREDS AMD trial participants. Using the eye as the unit of analysis and multifailure Cox proportional-hazards regression, the risk of AMD progression was related to dietary intake in the four arms of the trial. Results: Independent of AREDS supplementation, higher intakes of DHA (⩾64.0 vs trend = 0.01). Conclusions: The findings show an association of consuming a diet rich in DHA with a lower progression of early AMD. In addition to the AREDS supplement, a lower dGI with higher intakes of DHA and EPA was associated with a reduced progression to advanced AMD. Trial registration number: NCT00000145.Keywords
This publication has 23 references indexed in Scilit:
- International Tables of Glycemic Index and Glycemic Load Values: 2008Diabetes Care, 2008
- The Relationship of Dietary ω-3 Long-Chain Polyunsaturated Fatty Acid Intake With Incident Age-Related Macular DegenerationAmerican Journal of Ophthalmology, 2008
- Nutritional antioxidants and age-related cataract and maculopathyExperimental Eye Research, 2007
- The impact of EPA and DHA on blood lipids and lipoprotein metabolism: influence of apoE genotypeProceedings of the Nutrition Society, 2007
- Overview of Progress in the Epidemiology of Age-Related Macular DegenerationOphthalmic Epidemiology, 2007
- Dietary Intake of Antioxidants and Risk of Age-Related Macular DegenerationJama-Journal Of The American Medical Association, 2005
- Prospective Study of Intake of Fruits, Vegetables, Vitamins, and Carotenoidsand Risk of Age-Related MaculopathyAmerican Journal of Ophthalmology, 2004
- Associations between Antioxidant and Zinc Intake and the 5-Year Incidence of Early Age-related Maculopathy in the Beaver Dam Eye StudyAmerican Journal of Epidemiology, 1998
- The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male SmokersThe New England Journal of Medicine, 1994
- Cox's Regression Model for Counting Processes: A Large Sample StudyThe Annals of Statistics, 1982