Lack of Relation of Increased Malformation Rates in Infants of Diabetic Mothers to Glycemic Control during Organogenesis

Abstract
To determine how much insulin-dependent diabetes increases a woman's risk of giving birth to a malformed infant and how that risk is influenced by metabolic control, we followed 347 diabetic and 389 control women who enrolled in the study within 21 days of conception (the early-entry group) and 279 diabetic women who entered later (the late-entry group).