Autoantibodies to Variable Heavy (VH) Chain Ig Sequences in Humans Impact the Safety and Clinical Pharmacology of a VH Domain Antibody Antagonist of TNF-α Receptor 1
- 6 July 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Clinical Immunology
- Vol. 33 (7), 1192-1203
- https://doi.org/10.1007/s10875-013-9915-0
Abstract
To investigate the impact of a new class of anti-Ig autoantibodies reactive with variable heavy (VH) chain framework sequences (human anti-VH autoantibodies) on the pharmacology and safety of an anti-TNFR1 VH domain antibody (GSK1995057) in healthy human subjects.This publication has 33 references indexed in Scilit:
- Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hingeProceedings of the National Academy of Sciences of the United States of America, 2009
- Therapeutic cleavage of IgG is dangerous in humansTrends in Immunology, 2008
- Human F(ab′)2-containing immune complexes together with anti-hinge natural antibodies stimulate complement amplification in vitro and in vivoMolecular Immunology, 2008
- Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-GalactoseThe New England Journal of Medicine, 2008
- Blocking of Responses to Endotoxin by E5564 in Healthy Volunteers with Experimental EndotoxemiaThe Journal of Infectious Diseases, 2003
- Natural Anti-Immunoglobulin Autoantibodies: Irrelevant By-Products or Immunoregulatory Molecules?International Archives of Allergy and Immunology, 1998
- Comparison of the antiplatelet agent potential of the whole molecule, F(ab)2 and fab fragments of humanized anti-GPIIb/IIIa monoclonal antibody in monkeysGeneral Pharmacology: The Vascular System, 1996
- Natural antibodies against the immunoglobulin F(ab′)2 fragment cause elimination of antigens recognized by the F(ab′)2 from the circulationEuropean Journal of Immunology, 1995
- Association of IgA‐anti‐Fab autoantibodies with disease stage in head‐and‐neck cancerInternational Journal of Cancer, 1994
- Antibodies in Human Sera to F(a')2 Fragments of Monoclonal and Polyclonal IgGInternational Archives of Allergy and Immunology, 1981