The Continuing Spread of West Nile Virus in the Western Hemisphere
Open Access
- 15 October 2007
- journal article
- review article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 45 (8), 1039-1046
- https://doi.org/10.1086/521911
Abstract
West Nile virus (WNV) has historically been considered to be among the least virulent of the Japanese serogroup viruses of the family Flaviviridae, genus Flavivirus. However, recent epidemics associated with severe and fatal neuroinvasive disease have changed that perception. The emergence of a virus subtype with greater epidemic potential and virulence in the early 1990s facilitated the geographic expansion and westward spread of WNV; in 1999, it first appeared in the western hemisphere. Because of the broad host and vector range, the virus has become established in much of the region, and there is little chance that it will be eliminated. Transmission is difficult to predict and even more difficult to prevent and control. The cost-effectiveness of human WNV vaccines is uncertain. The building of laboratory diagnostic, epidemiologic, and vector-control capacity in WNV-enzootic countries is critical to the development of effective prevention and control strategies for WNV infection, as well as for other potential emerging vectorborne viral diseases.Keywords
This publication has 22 references indexed in Scilit:
- West Nile Virus: Epidemiology and Clinical Features of an Emerging Epidemic in the United StatesAnnual Review of Medicine, 2006
- Serologic Survey of Domestic Animals for Zoonotic Arbovirus Infections in the Lacandón Forest Region of Chiapas, MexicoVector-Borne and Zoonotic Diseases, 2003
- West Nile Virus Surveillance and Diagnostic: A Canadian PerspectiveCanadian Journal of Infectious Diseases, 2003
- West Nile virusThe Lancet Infectious Diseases, 2002
- West Nile Encephalitis: An Emerging Disease in the United StatesClinical Infectious Diseases, 2001
- Clinical Findings of West Nile Virus Infection in Hospitalized Patients, New York and New Jersey, 2000Emerging Infectious Diseases, 2001
- Epidemic West Nile encephalitis, New York, 1999: results of a household-based seroepidemiological surveyThe Lancet, 2001
- The Outbreak of West Nile Virus Infection in the New York City Area in 1999New England Journal of Medicine, 2001
- The West Nile Virus Outbreak of 1999 in New York: The Flushing Hospital ExperienceClinical Infectious Diseases, 2000
- Origin of the West Nile Virus Responsible for an Outbreak of Encephalitis in the Northeastern United StatesScience, 1999