Does Outflow Obstruction Exist in Hypertrophic Cardiomyopathy?
- 14 October 1982
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 307 (16), 1008-1009
- https://doi.org/10.1056/nejm198210143071609
Abstract
In this issue of the Journal, Pollick's report1 focuses on the ability of disopyramide to reduce or eliminate the echocardiographic and hemodynamic signs of left ventricular "outflow obstruction" in a small number of patients with muscular subaortic stenosis. This study suggests that the negative inotropic actions of this drug may produce hemodynamic improvement and increase exercise tolerance by eliminating intraventricular gradients. Although this study was uncontrolled and its conclusions must be considered preliminary, it does raise an important question: Is left ventricular outflow truly obstructed in hypertrophic cardiomyopathy?Since the concept of a functional stenosis of the left ventricle . . .Keywords
This publication has 11 references indexed in Scilit:
- Muscular Subaortic StenosisNew England Journal of Medicine, 1982
- The frontiers of cardiomyopathy.Heart, 1982
- Sudden death in hypertrophic cardiomyopathy: a profile of 78 patients.Cell Metabolism, 1982
- Therapy of hypertrophic cardiomyopathy: Medical or surgical? Clinical and pathophysiologic considerationsThe American Journal of Cardiology, 1981
- Hypertrophic cardiomyopathy: A disease in search of its own identityThe American Journal of Cardiology, 1980
- Idiopathic hypertrophic subaortic stenosis afflicted: Idols of the cave and the marketplaceThe American Journal of Cardiology, 1977
- Idiopathic Hypertrophic Subaortic StenosisCell Metabolism, 1968
- Dynamics of left ventricular emptying in hypertrophic subaortic stenosis: A cineangiographic and hemodynamic studyAmerican Heart Journal, 1967
- Pressure Gradients without ObstructionCirculation, 1965
- Pressure-Flow Studies in Hypertrophic Subaortic Stenosis *JCI Insight, 1964