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Data from Cadherin-11 Increases Migration and Invasion of Prostate Cancer Cells and Enhances their Interaction with Osteoblasts
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Data from Cadherin-11 Increases Migration and Invasion of Prostate Cancer Cells and Enhances their Interaction with Osteoblasts
Data from Cadherin-11 Increases Migration and Invasion of Prostate Cancer Cells and Enhances their Interaction with Osteoblasts
CH
Chih-Fen Huang
Chih-Fen Huang
CL
Cristina Lira
Cristina Lira
KC
Khoi Chu
Khoi Chu
MB
Mehmet Asim Bilen
Mehmet Asim Bilen
YL
Yu-Chen Lee
Yu-Chen Lee
XY
Xiangcang Ye
Xiangcang Ye
SK
Soo Mi Kim
Soo Mi Kim
AO
Angelica Ortiz
Angelica Ortiz
FW
Fe-Lin Lin Wu
Fe-Lin Lin Wu
CL
Christopher J. Logothetis
Christopher J. Logothetis
LY
Li-Yuan Yu-Lee
Li-Yuan Yu-Lee
SL
Sue-Hwa Lin
Sue-Hwa Lin
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30 March 2023
other
Published by
American Association for Cancer Research (AACR)
https://doi.org/10.1158/0008-5472.c.6500594
Abstract
Cell adhesion molecules have been implicated in the colonization of cancer cells to distant organs. Prostate cancer (PCa) has a propensity to metastasize to bone, and cadherin-11, which is an osteoblast cadherin aberrantly expressed in PCa cells derived from bone metastases, has been shown to play a role in the metastasis of PCa cells to bone. However, the mechanism by which cadherin-11 is involved in this process is not known. Here, we show that expression of cadherin-11 in cadherin-11–negative C4-2B4 cells increases their spreading and intercalation into an osteoblast layer and also stimulates C4-2B4 cell migration and invasiveness. The downregulation of cadherin-11 in cadherin-11–expressing metastatic PC3 cells decreases cell motility and invasiveness. Further, both the juxtamembrane (JMD) and β-catenin binding domains (CBS) in the cytoplasmic tail of cadherin-11 are required for cell migration and invasion, but not spreading. Gene array analyses showed that several invasion-related genes, including MMP-7 and MMP-15, are upregulated in cadherin-11–expressing, but not in cad11-ΔJMD–expressing or cad11-ΔCBS–expressing, C4-2B4 cells. These observations suggest that cadherin-11 not only provides a physical link between PCa cells and osteoblasts but also increases PCa cell motility and invasiveness that may facilitate the metastatic colonization of PCa cells in bone. Cancer Res; 70(11); 4580–9. ©2010 AACR.
Keywords
CADHERIN
INVASIVENESS
OSTEOBLAST
METASTASIS
MIGRATION AND INVASION
MMP
METASTASES
PROSTATE
CAD11
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