Comparative Nephrotoxicity of Cisplatin and Nedaplatin:Mechanisms and Histopathological Characteristics
Open Access
- 1 January 2011
- journal article
- Published by Japanese Society of Toxicologic Pathology in Journal of Toxicologic Pathology
- Vol. 24 (2), 87-94
- https://doi.org/10.1293/tox.24.87
Abstract
The antineoplastic platinum complexes cisplatin and its analogues are widely used in the chemotherapy of a variety of human malignancies, and are especially active against several types of cancers. Nedaplatin is a second-generation platinum complex with reduced nephrotoxicity. However, their use commonly causes nephrotoxicity due to a lack of tumor tissue selectivity. Several recent studies have provided significant insights into the molecular and histopathological events associated with nedaplatin nephrotoxicity. In this review, we summarize findings concerning the renal histopathology and molecular pathogenesis induced by antineoplastic platinum complexes, with a particular focus on the comparative nephrotoxicity of cisplatin and nedaplatin in rats.Keywords
This publication has 76 references indexed in Scilit:
- Transcriptional Regulation of Renal Cytoprotective Genes by Nrf2 and Its Potential Use as a Therapeutic Target to Mitigate Cisplatin-Induced NephrotoxicityJournal of Pharmacology and Experimental Therapeutics, 2010
- Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced NephrotoxicityCancer Cell, 2009
- The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicityAmerican Journal of Physiology-Renal Physiology, 2009
- Amelioration of Nedaplatin-Induced Nephrotoxicity by Continuous Infusion in RatsJournal of Toxicologic Pathology, 2007
- Effects of lipopolysaccharide on the appearance of macrophage populations and fibrogenesis in cisplatin-induced rat renal injuryExperimental and Toxicologic Pathology, 2004
- Protective Role of Heme Oxygenase-1 in Renal IschemiaAntioxidants and Redox Signaling, 2004
- Comparative Adverse Effect Profiles of Platinum DrugsDrug Safety, 1995
- Long‐term consequences of cis‐platinum‐induced renal injury: A structural and functional studyThe Anatomical Record, 1985
- The nephrotoxicity of cisplatinLife Sciences, 1983
- Cis-diamminedichlorplatinum-induced acute renal failure in the ratKidney International, 1982