A Case of Pemphigus Herpetiformis in a 12-Year-Old Male
Open Access
- 7 April 2011
- journal article
- Published by Hindawi Limited in ISRN Pediatrics
- Vol. 2011, 1-4
- https://doi.org/10.5402/2011/712560
Abstract
Pemphigus herpetiformis (PH) is one of the less common forms of pemphigus. PH in children is unreported. We describe a case of a child who developed PH. Observation. A 12-year-old boy was seen at our department with erosive plaques, vesicles, and crusted cutaneous lesions associated with severe itching persisting for six months. Histologic examination showed an intraepidermal bulla containing rare acantholytic epidermal cells with eosinophilic spongiosis. Direct immunofluorescence demonstrated intercellular Ig G and C3 deposit. The serum titer of antibodies against intercellular epidermal was 1/200 UI/l. Diagnosis of PH was made, and treatment with Dapsone 2 mg/kg per day resulted in total clinical remission. However, two months later, new vesicles reappeared and treatment was begun with prednisone at a dose of 2 mg/kg daily. There was a very good response. Discussion. Childhood pemphigus herpetiformis is a rare disease, often initially misdiagnosed. It must not be forgotten that the disease is a possible cause of erosive mucocutaneous disease in children.Keywords
This publication has 12 references indexed in Scilit:
- A case of pemphigus herpetiformis with absence of antibodies to desmogleins 1 and 3Journal of the European Academy of Dermatology and Venereology, 2009
- Childhood, neonatal, and stillborn pemphigus vulgarisInternational Journal of Dermatology, 1999
- Childhood pemphigusInternational Journal of Dermatology, 1999
- Misdiagnosis, Treatments, and Outcomes in the Immunobullous Diseases in ChildrenPediatric Dermatology, 1997
- Inflammatory Bullous Diseases in ChildrenDermatologic Clinics, 1993
- Is Pemphigus Herpetiformis an Entity?International Journal of Dermatology, 1987
- HERPETIFORM PEMPHIGUS, A VARIABLE PATTERN OF PEMPHIGUSInternational Journal of Dermatology, 1975
- Mixed bullous diseaseArchives of Dermatology, 1974
- Pemphigus controlled by sulphapyridineBritish Journal of Dermatology, 1973
- Acantholytic herpetiform dermatitisArchives of Dermatology, 1973