Luteolin, a Bioflavonoid, Attenuates Azoxymethane-Induced Effects on Mitochondrial Enzymes in Balb/c Mice
Open Access
- 30 November 2013
- journal article
- Published by Asian Pacific Organization for Cancer Prevention in Asian Pacific Journal of Cancer Prevention
- Vol. 14 (11), 6669-6672
- https://doi.org/10.7314/apjcp.2013.14.11.6669
Abstract
Colon cancer (CRC) is a serious health problem throughout the world. Development of novel drugs without side effects for this cancer is crucial. Luteolin (LUT), a bioflavonoid, has many beneficial effects such as antioxidant, anti-inflammatory and anti-proliferative potential. was a potent chemical carcinogen used for the induction of colon cancer. Colon carcinogenesis was initiated by intraperitoneal injection of azoxymethane (AOM) to mice at the dose of 15 mg/body kg weight in Balb/C mice for 3 weeks. Mice were treated with LUT at the dose of 1.2 mg /body kg weight orally. Mitochondrial enzymes such as isocitrate dehydrogenase (ICDH), α-keto dehydrogenase (α-KDH), succinate dehydrogenase (SDH) and the activities of respiratory chain enzymes NADH dehydrogenase and cytochrome c oxidase were found to be elevated in AOM-treated animals. Treatment with LUT decreased the activities of all the parameters significantly. Hence, LUT might be a potent anticancer agent against colorectal cancer.This publication has 23 references indexed in Scilit:
- Luteolin inhibits cell proliferation during Azoxymethane-induced experimental colon carcinogenesis via Wnt/ β-catenin pathwayInvestigational New Drugs, 2009
- Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesisBiomedicine & Pharmacotherapy, 2008
- Diallyl sulfide induces apoptosis in Colo 320 DM human colon cancer cells: involvement of caspase-3, NF-κB, and ERK-2Molecular and Cellular Biochemistry, 2008
- Anti-tumor promoting potential of luteolin against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ratsChemico-Biological Interactions, 2006
- DIETARY FLAVONOIDS: Bioavailability, Metabolic Effects, and SafetyAnnual Review of Nutrition, 2002
- REGULATION OF GENE EXPRESSION BY REACTIVE OXYGENAnnual Review of Pharmacology and Toxicology, 1999
- Mitochondrial Decay in Aging: Reversal through Supplementation of Acetyl‐l‐Carnitine and N‐tert‐Butyl‐α‐phenyl‐nitroneaAnnals of the New York Academy of Sciences, 1998
- Radioprotective effect of antioxidative flavonoids in γ-ray irradiated miceCarcinogenesis: Integrative Cancer Research, 1994
- Aging, cytochrome oxidase activity, and hydrogen peroxide release by mitochondriaFree Radical Biology & Medicine, 1993
- MICRODETERMINATION OF CYTOCHROME OXIDASE IN RAT TISSUES BY THE OXIDATION OF N-PHENYL-p-PHENYLENEDIAMINE OR ASCORBIC ACIDJournal of Histochemistry & Cytochemistry, 1963